丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

Are Low Molecular Weight Heparins the Same

互联网

436
Low molecular weight heparins (LMWHs) are glycosaminoglycans (GAGs) of different chain length, molecular weight distribution, and different physiochemical characteristics that result from their diverse methods of preparation, which make them non-interchangeable. The anticoagulant potency of heparin is measured as USP U/mg. This method is only applicable to LMWHs at high doses, when their anticoagulant properties are apparent. Anti-Xa activity has not enabled standardization of the biologic actions of LMWHs, since it does not address the ATIII-independent actions of LMWHs. Yet the European Pharmacopoeia Commission has adopted anti-Xa activity as a measure of LMWH potency. Since other markers of pharmacological activity also differ among LMWHs, their anti-IIa activity, tissue-factor pathway inhibitor (TFPI) releasing capacity, anti-inflammatory, and other cellular effects should be useful biomarkers in determining the biologic activity of each LMWH.
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序