Released Chromatin or DNA Fiber Preparations for High-Resolution Fiber FISH

When combined with molecular analysis and immunocytological localization, fluorescence in situ hybridization (FISH) represents one of the most direct and precise experimental tools in current biological research (1 -4 ). Direct visualization and in situ detection fill the gap between molecular analysis and cytological description and provide a new avenue for in vitro and in vivo comparison. Such a system facilitates the understanding of cellular events not only with respect to what and how, but also where and when.