Experimental Designs for the Study of ReceptorReceptor Interactions

With the rise of interest in receptor–receptor interaction research, optimization of experimental designs to study the nature of interactions has become increasingly important. In this chapter, traditional experimental designs and their associated statistics are reviewed, and their theoretical and practical limitations are described. The logic and theory behind isobolographic analysis is explained and their practical use is also described. As more and more receptor–receptor interactions are recognized with the use of two or more GPCR drugs, advances in the analysis of the type presented here will become more significant and important for clinical pharmacotherapy.