【求助】有什么办法可以阻滞LPS刺激的TNF-alpha分泌？

丁香园论坛2015-08-21

1339

sonny_zan

我实验的关键步骤，现在就是不知道有什么办法可以阻滞LPS刺激后PBMC分泌TNF-alpha，考虑过用p38 MAPK抑制剂SB203580，后来查到一篇文献说SB203580对LPS刺激后p38 MAPK的活性影响甚微或无。
请各位大侠给点意见啦！我快急死了~~~

xiongran

拿抗体把PBMC表面的TLR4封闭掉试试看！

pureclear

可以考虑用TNF-a的中和抗体可以中和细胞产生的TNF-a R&D公司有

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