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Measurement of DNA Damage Using the Comet Assay

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381
Nitric oxide (NO) has the potential to damage DNA directly, and also to react with O2 to form the nitrosating species N2 O3 or to react with O2 to form the powerful oxidizing agent peroxynitrite (see Chapter 20 , this volume). The DNA-damaging activity of NO has been reviewed by Tannenbaum et al. (1 ).
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