Differentiation of Mouse Thymocytes in Fetal Thymus Organ Culture
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Most T cells develop in the thymus. Thymic development of T cells offers an excellent experimental system to pursue many issues of developmental biology, including
| 1. | lineage decisions, e.g., CD4+ T cells vs CD8+ T cells, and TCR-αβ+ T cells vs TCR-γδ+ T cells, |
| 2. | clonal selection, e.g., positive selection of useful T-cell clones and negative selection of harmful T-cell clones, and |
| 3. | cell migration, e.g., entry into and emigration from the thymus. |
