Overview of Whole-Genome Essentiality Analysis

Genomic sequencing has transformed modern biology into an age of global analysis of gene expression, protein pathways, and metabolic networks. To understand wholecell function, biologists and bioinformaticians in many fields have developed a diverse set of methods and tools to identify genes essential to a particular organism under a particular set of conditions. Gene Essentiality: Protocols and Bioinformatics reviews many of these diverse techniques and experimental procedures developed to analyze entire genomes of a variety of prokaryotes and eukaryotes.