Establishment of Ovarian Cancer Cell Lines

互联网2014-02-13

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Human tumor cell lines have provided valuable model systems to study a wide variety of tumor characteristics including the cell biology, genetics, and chemosensitivity profiles of disease. A large number of ovarian cancer cell lines have now been established and are in widespread use Table 1 ) (1 -15 ). Many of these have been selected to reflect specific situations, e.g., pre- and postchemotherapy models or different histo- logical subtypes.

Table 1 Properties of Established Ovarian Carcinoma Cell Lines

			Prior
Cell Line	Histology	Source	Treatment	Ref.
PE01	P.D. Serous adenoca	Ascites	P/FU/CHL	1
PE04	P.D. Serous adenoca	Ascites	P/FU/CHL	1
PE06	P.D. Serous adenoca	Ascites	P/FU/CHL	2
PEA1	P.D. Adenoca	Pleural	None	2
PEA2	P.D. Adenoca	Ascites	P/Pred	2
PE016	P.D. Serous adenoca	Ascites	Radioth	2
PE014	W.D.Serous adenoca	Ascites	None	2
T014	W.D.Serous adenoca	Sol. Met	None	2
PE023	W.D.Serous adenoca	Ascites	P/CHL	2
SKOV-3	Adenoca	Ascites	T	3
SW626	Adenoca	―	―	3
OVCAR-2	Adenoca	Ascites	P/Cy	4
OVCAR-3	P.D. papillary adenoca	Ascites	P/Cy/Adr	5
OVCAR-4	Adenoca	Ascites	P/Cy/Adr	6
OVCAR-5	Adenoca	Ascites	None	7
OAW 28	Adenoca	Ascites	P / Mel	8
OAW 42	Serous adenoca	Ascites	P	8
41M	Adenoca	Ascites	None	9
59M	Endometr adenoca	Ascites	None	8
CH1	Papillary adenoca	Ascites	P/ JM8	8
138D	Serous adenoca	Ascites	Carb	9
180D	Adenoca	Ascites	P	9
200D	Serous adenoca	Solid	None	9
253D	Serous adenoca	Ascites	Cy/MPA	9
HOC-1	W.D. Serous adenoca	Ascites	None	10
HOC-7	W.D. Serous adenoca	Ascites	None	10
CAOV-3	Adenoca	Tumour	Cy/Adr/FU	10
COLO 110	Serous adenoca	Sol. Met	None	11
COLO 316	Serous adenoca	Pleural	None	11
COLO 319	Serous adenoca	Ascites	None	11
COLO 330	Serous adenoca	Ascites	Mel/Radiother	11
IGROV1	Adenoca	Primary	None	12
HTOA	W.D. serous adenoca	Primary	None	13
OV-1063	Papillary adenoca	Ascites	Cy/Adr/P/HMM	14
DO-s	W.D. mucinous adenoca	Ascites	―	15

P.D. = Poorly differentiated; W.D. = Well differentiated; adenoca = adenocarcinoma; pleural = pleural effusion; Sol.met. = solid metastasis; P = cisplatin; FU = 5-fluorouracil; CHL = chlorambucil; Pred = prednimustine; Radioth = radiotherapy; T = thiotepa; Cy = cyclophosphamide; Adr = adriamycin; Mel = melphalan; Carb = carboplatin; MPA = medroxyprogesterone actetate; HMM = examethylmelamine.