Molecular Analysis of Chromosome Aberrations in Hematological Malignancies: Southern Hybridization
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Since the first reports of the Philadephia chromosome in chronic myelogenous leukemia (CML), nonrandomly occurring chromosome abnormalities have been described in a number of leukemias and lymphomas (1 ,2 ). The identification of the DNA sequences that span the translocation breakpoints in several hematological malignancies, and the cloning and sequencing of the inmiunoglobulin and T-cell receptor genes, have created the ability to reliably diagnose and monitor these diseases with molecular-based techniques that complement the analysis of banded metaphase chromosomes (3 ).
