Assessing Epilepsy-Related Behavioral Phenotypes in Adult Zebrafish

Over the past decades, zebrafish have been presented as a novel and valuable tool for modeling complex human diseases. Epilepsy is a serious brain disorder with multiple genetic and environmental causes. Our poor understanding of its pathogenesis requires novel paradigms and model organism for translational experimental epilepsy research. Seizure-like behavior has already been studied in both larval and adult zebrafish models, including genetically modified strains and convulsant drugs. This protocol describes how to quantify seizure-like behavioral phenotypes commonly observed in adult zebrafish models of epilepsy.