Immunohistochemical Analysis of Adhesion Molecules in Airway Biopsies

互联网2014-02-14

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Adhesion molecules are receptors found on the surface of leukocytes and endothelial cells, which bind to their ligands, either on other cells or on the extracellular matrix. The function of adhesion molecules is to allow leukocytes to interact with other hemopoetic cells or with foreign antigens (Ags) in the blood, to transiently adhere to the vascular endothelium, to migrate between endothelial cells and through the basement membrane into the surrounding tissue, and to adhere to the epithelium. There are three main groups of adhesion molecules: the integrins, immunoglobulin (Ig) supergene family, and the selectins: These are summarized in Table 1 (1 –7 ).

Table 1 Summary of Adhesion Molecules

Group	CD number	Name	Expressed on	Ligand
Integrins	CD 49a	VLA-1	T lymphocytes, fibroblasts, basement membrane	Laminin, collagen
B1 very late antigens	CD 49b	VLA-2	Activated T lymphocytes, platelets, fibroblasts, endothelium, epithelium	Collagen, laminin
	CD 49c	VLA-3	Epithelium, fibroblasts	Laminin, collagen, fibronectin
	CD 49d	VLA-4	Leukocytes, fibroblasts	VCAM-1, fibronectin
	CD 49e	VLA-5	Leukocytes, platelets, epithelium	Fibronectin
	CD 49f	VLA-6	T lymphocytes, platelets	Laminin
B2 leukocyte integrins	CD 11a	LFA-1	Leukocytes	ICAM-1, ICAM-2, ICAM-3
	CD 11b	Mac-1	Macrophages, monocytes, granulocytes	ICAM-1, fibrinogen, C3bi
	CD 11c	p150.95	Macrophages, monocytes, granulocytes	Fibrinogen, C3bi
IG Supergene family	CD 54	ICAM-1	Endothelium, leukocytes, epithelium	LFA-1 Mac-1
	CD 102	ICAM-2	Endothelium, leukocytes	LFA-1
	CD 106	VCAM-1	Endothelium, dendritic cells, tissue macrophages	VLA-4
Selectins	CD 62E	E selectin	Endothelium	Sialyl Lewis x
	CD 62P	P selectin	Platelets, endothelium	Sialyl Lewis x
	CD 62L	L selectin	Leukocytes	Mannose-6-P, fructose-6-P

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