丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

High-Level Expression and Purification of Human Hepatic Lipase from Mammalian Cells

互联网

444
Through its ability to catalyze the hydrolysis of triglycerides and phospholipids, hepatic lipase (HL) has been shown to influence the metabolism of a broad range of circulating lipoproteins (1 ). HL is synthesized and secreted by hepatocytes and is found bound, through an ionic interaction with heparan sulfate proteoglycans, to the luminal surface of endothelium lining the liver sinusoids (2 ). The detection of HL catalytic activity in the ovary and adrenal gland, but not protein synthesis, suggests that HL is transported and binds specifically to these tissues as well (3 ,4 ). In addition, there is evidence to suggest that, independent of its catalytic activity, HL can act as a ligand to facilitate the uptake of remnant lipoproteins through its interaction with cell surface proteoglycans and/or cell surface receptors (5 8 ).
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序