Development and Applications of Animal Models of Thrombosis

Of more than 2 million deaths in the United States each year (from all causes), nearly 1 million are caused by cardiovascular disease (CVD). CVD claims more lives each year than the next seven leading causes combined. The prevalence of CVD in the United States is indicated by the statistics: 50 million people with high blood pressure, 12.5 million people with coronary heart disease (CHD) (7.2 million with myocardial infarction [MI]; 6.3 million with angina pectoris), 4.4 million with stroke, 4.6 million with congestive heart failure, and 2.8 million suffering from other CVD diseases.