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Effect of Lectins on Uptake of Polyamines

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The aliphatic polyamines (putrescine, cadaverine, spermidine, and spermine) are flexible polycations, since under physiological conditions they exhibit 2, 3, or 4 positive charges, respectively, and are able to rotate around the carbon-carbon or carbon-nitrogen bonds, imparting conformational flexibility ( see Fig. 1 ).
 
Fig. 1.  The structure of the most common polyamines.

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