The Complement System:An Overview
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Component |
Structure |
Plasma conc (mg/L) |
---|---|---|
Classical Pathway |
||
C1 |
Complicated molecule, composed of 3 subunits, C1q (460 kDa), C1r (80 kDa), C1s (80 kDa) in a complex (C1qr 2 s 2 ) |
180 |
C4 |
3 chains (α, 97 kDa; β, 75 kDa, γ, 33 kDa); from a single precursor |
600 |
C2 |
single chain, 102 kDa |
20 |
Alternative Pathway |
||
fB |
single chain, 93 kDa |
210 |
fD |
single chain, 24 kDa |
2 |
Properdin Common: |
oligomers of identical 53 kDa chains |
5 |
C3 |
2 chains: α, 110 kDa, β, 75 kDa |
1300 |
Terminal Pathway |
||
C5 |
2 chains: 115 kDa, 75 kDa |
70 |
C6 |
single chain, 120 kDa |
65 |
C7 |
single chain, 110 kDa |
55 |
C8 |
3 chains: α, 65 kDa, β, 65 kDa γ, 22 kDa |
55 |
C9 |
single chain, 69kDa |
60 |