Factor Xa Inhibitors

Serine proteases play an important role in the process of thrombogenesis. In the coagulation network, various serine proteases are activated that facilitate the formation of factor Xa (1 ). The serine protease factor Xa has a central role in coagulation and platelet activation. Factor Xa is an essential component of the prothrombinase complex, and leads to the formation of thrombin. Thus, the inhibition of factor Xa represents an important strategy in the development of new antithrombotic drugs.