Preparation of CollagenGlycosaminoglycan Copolymers for Tissue Regeneration

Certain analogs of the extracellular matrix (ECM) have been shown to possess surprising morphogenetic activity during healing of lesions in various anatomical sites. This chapter describes methods for synthesis of the two ECM analogs that have been studied most extensively. The reader is referred to descriptions of these methods in the original literature (1 –3 ). The biological activity of ECM analogs has been reviewed elsewhere (4 ).