Macromolecular Delivery Across the BloodBrain Barrier

The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood–brain barrier (BBB). Noninvasive, transient, and local image-guided blood–brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery.