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Murine Monoclonal Antibody Development

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2126
Major advances in the analysis of biomolecular structure have emerged from the development of highly specific monoclonal antibodies (MAb) by K�hler and Milstein in 1975 (1 ). MAb are produced from hybridoma cell lines that secrete a single species of antibody to a unique antigen. The advantages of MAb as reagents for antibody engineering are:
1. 
They are extremely pure immunological reagents that can be produced by immunization with a heterogenous antigenic preparation;
2. 
They are homogenous with respect to affinity and specificity;
3. 
The specificity of the antibody is directed to a single epitope;
4. 
The desired MAb can be selected for activity, affinity, and subclass by applying appropriate screening methods; and
5. 
Virtually unlimited quantities of MAb can be produced.
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