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In Vitro Models of the BloodBrain Barrier

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411
The chapter provides an introduction and brief overview of currently available in vitro blood–brain barrier models, pointing out the major advantages and disadvantages of the respective models and potential applications. Bovine brain microvessel endothelial cell isolation, culture, and transendothelial permeability measurement procedures are discussed in detail as a model system for a laboratory to begin brain vascular investigations.
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