Methods for the Identification of Host Receptors for Shiga Toxin
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The Shiga toxin receptor glycolipid Gb3 (globotriaosylceramide) is also known as the pk blood group antigen (1 ) and as CD77, a germinal center B-cell differentiation antigen (2 ). Tissue localization of Gb3 is associated with sites of Stx-induced pathology in animal models (3 –5 ) and in humans (6 ) and, as such, is a major determinant of Stx1-induced disease.
